The inaugural meeting of the Joint Monitoring Committee (JMC) of the Poland-Russia CBC Programme 2014-2020 took place on 23rd March 2017 in Yantarny (Kaliningrad Oblast). The JMC members took important decisions for the proper implementation of the Programme. The Rules of Procedure of the JMC were approved and the documents crucial for launching the first call for proposals were discussed. Much attention was paid to the Programme Manual (part 1. Applicant), which was prepared by the Ministry of Economic Development (Managing Authority of the Programme) and the Joint Technical Secretariat. The Programme Manual contains all information necessary for future applicants to prepare joint Polish-Russian projects. A new solution for the beneficiaries, who are familiar with the Lithuania-Poland-Russia CBC Programme 2007-2013, is the way of submitting the applications, which will be prepared and submitted to the Joint Technical Secretariat in electronic forms only. The launch of the first call for proposals is planned for July 2017.